Vestards Šimkus started to play the piano in age of 5. From 1990 until 2002, he studied in Emīls Dārziņš Music School in Riga, where his teachers were Ruta Švinka, Ligita Muižarāja, Teofils Biķis and Sergejs Osokins. In 2002/2003, he studied at the University of Southern California under Daniel Pollack. From 2004 to 2006, he studied at the Reina Sofía School of Music in Madrid under Dimitri Bashkirov and Claudio Martinez Mehner. In 2006 to 2008, he studied at the Richard Strauss Konservatorium in Munich under Vadim Suchanov. Shimkus has also studied composition for five years under the renowned Latvian contemporary composer Pēteris Vasks. He performs improvised concerts, composes for cinema and takes part in experimental events with actors and performance artists.

International recognition came to Vestard Šimkus after his debut performances with BBC Philharmonic, City of Birmingham Symphony Orchestra, Orchestre National de France, Czech Philharmonic, KREMERata Baltica, NDR Symphony Orchestra of Hamburg.

He has also played chamber music with Borodin Quartet, Vertavo Quartet, Ciurlionis Quartet, Quatuor Leonis and others. As a solo pianist, he has performed in major concert halls around the world, including Konzerthaus (Vienna), Konzerthaus Berlin, Tokyo Opera City, Radio France (Paris), Berwaldhallen (Stockholm), Konserthuset (Stockholm), Moscow Conservatory, Palau de la Musica (Barcelona), Sala Verdi (Milano), and Oriental Art Center (Shanghai).

His repertoire ranges from Baroque Music to the contemporary music of the 21st century. He often plays recitals where classical works form a dialogue with the recent contemporary music, including his own compositions. He occasionally performs entirely improvised solo concerts inspired by jazz, contemporary classical music, film music, early music and folk music.

Šimkus has written two piano concertos and a number of solo piano and chamber music works, some of which have been published by Schott Verlag, as well as music for cinema and theatre.